血清25-基维生素D的关系,肥胖与新出现的阻塞性睡眠呼吸暂停
Yuanyuan Zhang1, Yanjun Zhang1, Ziliang Ye1
1Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, 510515, China.
International journal of obesity (2005)
|October 27, 2023
概括
较高的维生素D水平与阻塞性睡眠呼吸暂停 (OSA) 的风险较低有关,特别是在肥胖的人群中. 维持足够的维生素D可能有助于预防高危人群中OSA的发展.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 营养科学 营养科学
背景情况:
- 维生素D和阻塞性睡眠呼吸暂停 (OSA) 之间的关系尚未完全理解.
- 血清25-基维生素D (25(OH) D是维生素D状态的关键指标.
- 肥胖是已知的OSA风险因素之一.
研究的目的:
- 为了研究血清25(OH) D水平与新发性OSA的发病率之间的关联.
- 为了检查肥胖是否改变了维生素D和OSA风险之间的关系.
主要方法:
- 一项前性队列研究涉及英国生物银行444,975名参与者.
- 参与者在基线时没有OSA.
- 新发性OSA是主要结局,随访时间中位数为12.0年.
主要成果:
- 在血清25(OH) D和新发性OSA风险之间观察到一个整体的反向关联 (HR每SD增量:0.92).
- 这种反向关联主要在BMI≥25kg/m2和腰围≥90cm的参与者中具有意义.
- 在BMI或腰围较低的参与者中没有发现显著的关联 (P-相互作用 = 0.004).
结论:
- 血清25(OH) D与肥胖患者新发性OSA风险有相反的关系.
- 较高的维生素D水平可能在患有肥胖症的人群中起到主要预防OSA的作用.
- 建议维持足够的维生素D状态,以预防肥胖人口的OSA.
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