各国之间的运输比较有效性证据:对健康技术评估的考虑
Alex J Turner1, Cormac Sammon1, Nick Latimer2,3
1Putnam PHMR, London, UK.
PharmacoEconomics
|October 27, 2023
概括
本研究介绍了用于健康技术评估 (HTA) 的可运输性方法. 它涉及使用来自不同人群的真实数据来确保证据的相关性并支持HTA决策.
科学领域:
- 医疗技术评估 (HTA) 是指对医疗技术进行评估.
- 现实世界的证据 (RWE)
- 相对有效性研究研究比较
背景情况:
- 卫生技术评估机构优先考虑比较有效性证据的内部有效性.
- 越来越多地使用外部真实世界的数据,引发了对外部有效性或可传输性的担忧.
- 由于可运输性挑战,人们倾向于使用本地数据.
研究的目的:
- 为了在卫生技术评估的背景下提供对可运输性的介绍.
- 要总结假设和方法来识别和调整缺乏可运输性.
- 讨论在HTA框架内使用可运输性方法的考虑因素.
主要方法:
- 审查现有方法来解决现实世界的证据的可转移性.
- 讨论用于识别效果修饰剂和选择目标人群的指导.
- 探索如何将可运输性评估纳入HTA提交和决策流程.
主要成果:
- 现有方法可以通过考虑跨国差异来解决可运输性问题.
- 由于知识差距和整合不确定性,目前在HTA中对这些方法的考虑是有限的.
- 需要指导,以便在HTA中有效利用可运输性方法.
结论:
- 便携性对于在医疗技术评估中利用现实世界的数据至关重要.
- 需要进一步开发和整合可运输性方法来增强HTA.
- 本文为理解和应用HTA环境中的可运输性提供了一个框架.
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