TiO2纳米颗粒通过引起前转移性细胞外囊泡来促进瘤转移
Xupeng Mu1, Kebang Hu2, Anhui Wei3
1Scientifc Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Journal of nanobiotechnology
|October 27, 2023
概括
二氧化纳米颗粒 (TiO2 NPs) 可以通过改变瘤衍生的细胞外囊泡 (EVs) 来意外地增强癌症转移. 这些NP触发了促进血管生成和转移前的形成的EV,突出显示了纳米医学中的风险.
科学领域:
- 纳米医学是一种纳米医学.
- 癌症生物学 癌症生物学
- 分子瘤学分子瘤学
背景情况:
- 纳米技术提供了癌症诊断和治疗潜力.
- 一些研究表明,纳米粒子 (NP) 可能矛盾地促进瘤的进展.
- 已知瘤衍生的细胞外囊泡 (EVs) 可以促进转移.
研究的目的:
- 调查纳米材料,特别是TiO2NP是否通过瘤衍生的EVs促进瘤进展.
- 阐明NP诱导的前转移性EVs的潜在分子机制.
主要方法:
- 使用TiO2NP和癌症模型的体外和体内实验.
- 从NP处理的瘤中释放的细胞外囊泡 (EVs) 的分析.
- 分子分析包括miRNA测序和特定细胞通路的向 (VEGFR2,VE-cadherin,S1PR1).
主要成果:
- 在体外和体内,TiO2 NPs触发了瘤衍生的EVs,并增强了前转移能力.
- 由NP引起的EV将miR-301a-3p输送到血管内皮细胞中.
- 这导致了通过向S1PR1来抑制VEGFR2和VE-cadherin,破坏了血管完整性,促进了透性和血管生成,并形成了转移前的.
结论:
- TiO2 NPs可以通过调节瘤衍生的EVs来促进癌症转移.
- 这项研究揭示了一种涉及miR-301a-3p和血管内皮细胞通路的新奇机制.
- 在癌症治疗中安全的纳米药物设计需要紧急考虑NP对EV的影响.
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