坚持硫微生物饮食和卵巢癌生存率:来自前性队列研究的证据
Qi Cui1,2,3, Ting-Ting Gong4, Fang-Hua Liu5,6
1Department of Frigidzone Medicine, College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Molecular nutrition & food research
|October 28, 2023
概括
富含红色和加工肉类的高硫微生物饮食与卵巢癌 (OC) 患者的生存率较差有关. 这种饮食模式增加了OC妇女所有原因死亡的风险.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 微生物组研究 微生物组研究
背景情况:
- 卵巢癌 (OC) 存活率受到包括饮食在内的各种因素的影响.
- 肠道微生物组在癌症的发展和进展中起着重要作用.
- 饮食模式可以调节肠道微生物组的组成和功能.
研究的目的:
- 研究硫微生物饮食与卵巢癌 (OC) 患者的生存结果之间的关联.
- 为了确定饮食中硫的摄入是否会影响OC幸存者的全因死亡率.
主要方法:
- 一项前性队列研究,涉及2015年至2020年期间诊断的703名卵巢癌患者.
- 通过使用经过验证的食物频率问卷来评估饮食摄入量.
- 死亡率数据是通过死亡登记册链接收集到2021年3月31日.
主要成果:
- 在平均37.2个月的随访期间,发生了130例死亡.
- 较高的硫微生物饮食得分与增加全因死亡风险显著相关 (HR=1.93对于最高与最低的三位数).
- 硫微生物饮食得分每增加1个SD,死亡风险增加33% (95% CI:1.04-1.71).
结论:
- 坚持硫微生物饮食,以高红肉/加工肉和低水果/蔬菜/全谷物摄入量为特征,与OC患者的生存率差相关.
- 诊断后的饮食修改可能会影响生存结果.
- 特定的子组,包括老年患者和BMI较高的患者,显示出显著的关联.
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