在患有大麻使用障碍的个体中循环内分泌大麻素和N-乙乙醇胺-初步发现
Nadia Boachie1,2, Erin Gaudette1,2, Richard P Bazinet3
1Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON N6B 1Y6, Canada.
Brain sciences
|October 28, 2023
概括
在患有大麻使用障碍 (CUD) 的人群中,循环内分泌的内分泌素,如安纳胺 (AEA) 和N-乙烯基乙醇胺 (NAE) 的水平升高. N-docosahexaenoylethanolamine (DHEA) 显示与大麻渴望有着相反的关系.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 成研究 研究成研究
背景情况:
- 内大麻素和N-乙乙醇胺 (NAE) 是涉及生理功能,心理健康和成的生物活性脂质.
- 慢性大麻使用会影响内分泌系统,但大麻使用障碍 (CUD) 中的循环NAE水平仍然不清楚.
研究的目的:
- 与健康对照人群相比,对患有CUD的个体的内分泌素和NAE的血度进行调查.
- 探索这些脂质水平,大麻使用参数和渴望之间的潜在相关性.
主要方法:
- 从11名CUD患者和54名健康对照者 (HC) 的血样本使用高性能液态染色体质谱分析.
- 关键分析物包括2 - 阿拉基多诺伊尔甘油醇 (2 - AG),N - 阿拉基多诺伊尔乙醇胺 (AEA),N - 多可萨赫萨埃诺伊尔乙醇胺 (DHEA) 和N - 奥利奥伊尔乙醇胺 (OEA).
- 参与者对FAAH基因变异 (rs324420) 进行基因定型.
主要成果:
- 与HC相比,患有CUD的个体表现出明显更高的AEA,OEA和DHEA度.
- 内分泌大麻素2-AG显示了CUD的边际升高.
- DHEA度与大麻的渴望相反相关 (r = -0.86,p = 0.001).
- 在脂质水平和大麻分析物,使用频率或戒断症状之间没有发现显著的相关性.
结论:
- 初步发现表明,慢性大麻使用者体内内大麻系统活性升高.
- 观察到的升高可能代表一个补偿反应或一个先前存在的状态.
- 需要进一步的研究来检查长期戒断期间的NAE以及DHEA在渴望中的作用.
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