在精神分裂症患者中,社交互动的关键大脑网络的缺陷
Yiwen Wu1, Hongyan Wang1, Chuoran Li1
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Brain sciences
|October 28, 2023
概括
精神分裂症 (SZ) 患者表现出与奖励和情绪网络中大脑活动改变相关的社会缺陷. 休息状态的功能性MRI显示了低频波动 (ALFF),分数ALFF (fALFF) 和区域均性 (ReHo) 的幅度的特定变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症 (SZ) 的特点是社会功能显著受损.
- 奖励网络和情绪突出网络对于社交互动至关重要.
- 了解SZ社会赤字的神经支柱至关重要.
研究的目的:
- 调查SZ患者在奖励和情绪突出网络中的休息状态功能MRI测量的变化.
- 为了检查低频波动 (ALFF) 的幅度,分数ALFF (fALFF),区域同质性 (ReHo) 和功能连接性 (fc) 在SZ患者与健康对照者相比.
主要方法:
- 从30名SZ患者和30名匹配的健康对照人群获得了MRI扫描.
- 在奖励和情绪突出网络的关键大脑区域分析了静止状态的ALFF,fALFF和ReHo.
- 评估了杏仁体,轨道前皮层 (OFC) 和胰岛之间的静止状态功能连接 (rs-fc).
主要成果:
- SZ患者在右尾骨和右骨中显示ALFF增加.
- 在SZ患者的双边尾骨,骨和骨中观察到增加的fALFF和ReHo.
- 在SZ患者中发现,双边胰岛的fALFF减少,右侧OFC和左桃体之间的rs-fc减少.
结论:
- 在奖励和情绪突出网络中的异常静止状态ALFF,fALFF,ReHo和fc与精神分裂症的社会功能受损有关.
- 这些发现提供了对SZ社会互动缺陷背后的神经机制的见解.
- 建议使用基于网络的分析和任务状态fMRI进行进一步的研究,以探索实时社交互动机制.
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