中度至重度阻塞性睡眠呼吸暂停综合征患者的认知功能,重点是执行功能和决策能力
Lei Zhao1, Yanyan Zhao1, Dongmei Su1
1Department of Respiratory Medicine, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Heifei 230011, China.
Brain sciences
|October 28, 2023
概括
患有中度至重度阻塞性睡眠呼吸暂停综合征 (OSAS) 的患者表现出决策能力受损,选择更具风险的选择,并经历较差的财务结果. 这种认知功能障碍可能源于前额叶皮层活动减少.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 认知心理学 认知心理学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 与认知缺陷有关.
- 在OSAS患者中,决策功能在很大程度上仍未被探索.
研究的目的:
- 研究中度至重度OSAS患者的决策能力.
- 评估使用子游戏任务 (GDT) 的风险决策.
主要方法:
- 与30名中度至重度OSAS患者和27名轻度/无OSAS对照进行了比较.
- 使用子游戏任务 (GDT) 来评估风险决策.
- 评估基线数据的一般认知和执行功能.
主要成果:
- 中度至重度OSAS患者选择更安全的选择的频率较低 (p=0.022).
- 在OSAS患者中,风险较高的选择使用率更高,负面反率更低 (p=0.022,p=0.001).
- 奥萨斯集团的负面财务结果显著增加 (p<0.001).
结论:
- 中度至重度的OSAS患者表现出决策能力受损.
- 执行功能缺陷,可能是由于前额叶皮层活动减少,是这种障碍的基础.
- 记忆,注意力,语言和定向功能似乎相对保留.
相关概念视频
Sleep Apnea
164
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
164
High-Level and Low-Level Awareness
274
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
274
Role of Cerebellum and Prefrontal Cortex in Memory
449
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
449
Cognitive Development During Adulthood
125
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
125
Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Substance Use Disorders Affecting Sleep
174
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
174


