在患有视觉幻觉的帕金森病患者的大脑小脑功能连接的差异和变化
Liangcheng Qu1, Chuan Liu1, Yiting Cao2
1Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210019, China.
Brain sciences
|October 28, 2023
概括
帕金森病 (PD) 患有幻觉 (PD-H) 的患者的功能连接受损,特别是在小脑区域. 小脑功能连接 (FC) 显示为诊断PD-H的生物标志物具有前途,达到90%以上的准确性.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 机器学习 机器学习
背景情况:
- 在帕金森病 (PD) 患有幻觉 (PD-H) 的患者中,功能连接受损,甚至在临床前.
- 小脑在认知中的作用表明其功能连接 (FC) 可能在PD-H中发生变化.
- 在PD-H中澄清小脑FC对于理解疾病机制和开发诊断工具至关重要.
研究的目的:
- 研究与健康对照组 (HC) 相比,与帕金森病 (PD-H) 和没有幻觉 (PD-NH) 的帕金森病 (PD) 患者的小脑功能连接 (FC) 的变化.
- 评估小脑FC作为生物标志物的潜力,以使用机器学习来对PD-H进行分类.
- 探索小脑FC变化与PD认知表现之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 数据从17名PD-H患者,13名PD-NH患者和26名HC患者获得.
- 对小脑功能连接 (FC) 进行了分析,以确定群体之间的差异.
- 支持矢量机器 (SVM) 用于使用小脑FC作为训练特征来分类受试者.
主要成果:
- 与HC相比,PD-H患者在左前内 (PCUN) 呈现出增加的FC.
- 与PD-NH患者相比,PD-H患者在双边下部额回 (IFG),左侧后部中心回 (PoCG),下壁叶 (IPL) 和PCUN中显示出增加的FC.
- 在PD-H分类中,Cerebellar FC实现了超过90%的识别准确度,证明了其作为生物标记物的有效性.
结论:
- 在PD-H和PD-NH患者中,皮层-大脑的FC显著受到干扰,具有不同的模式.
- 脑FC作为一种有效的生物标志物用于识别PD-H.
- 拟议的方法为诊断临床前PD-H和潜在的其他神经退行性疾病提供了一个有希望的,低成本的方法.
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