中耳假肢中的挤出和脱位:文学评论
Pietro Canzi1,2, Elena Carlotto2, Luca Bruschini3
1Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Brain sciences
|October 28, 2023
概括
中耳重建的假肢,包括部分骨置换假肢 (PORP) 和全骨置换假肢 (TORP),平均挤出或脱位率为5.2%. 需要进一步的生物工程研究来改善假肢适应性,并克服目前预测功能结果的局限性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物材料科学 生物材料科学
- 手术创新 在外科创新.
背景情况:
- 假肢被用于中耳 (ME) 重建,因为它们的声学好处.
- 包括在内的合成ME材料的一个重大挑战是潜在的宿主排斥.
- 挤出和脱位是已知的并发症,影响这些植入物的疗效.
研究的目的:
- 对部分骨置换假肢 (PORP) 和全骨置换假肢 (TORP) 的挤出和脱位率进行文献综述.
- 分析与这些假肢相关的功能结果,特别是与这些假肢相关的气骨间隙改善.
- 确定当前的局限性,并建议未来改善ME重建植入物的方向.
主要方法:
- 80篇文章的系统文献审查.
- 用于文章选择的包含和排除标准.
- 对挤出/脱位率和气骨间隙改善的分析.
主要成果:
- 对于ME重建的最常见的指示是慢性中耳炎与胆固醇瘤.
- 假肢的平均挤出或脱位率为5.2%,范围广泛 (0-35%).
- 空气与骨间隔的平均改善为PORP的12.1dB,TORP的13.8dB.
结论:
- 对于ME重建的假肢的数据显示出很高的变异性,使功能结果变得不可预测.
- 当前的技术局限性阻碍了在中耳环境中对假肢的最佳适应.
- 生物工程的进步对于开发改进的ME假肢至关重要,这些假肢可以更好地与宿主组织集成.
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