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在韩国人群中探索使用和确定阿波蛋白B测试的参考间隔

Rihwa Choi^1,2, Sang Gon Lee¹, Eun Hee Lee³

¹Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of Korea.

Diagnostics (Basel, Switzerland)

|October 28, 2023

概括

这项研究确定了韩国成年人中Apolipoprotein B (ApoB) 的参考间隔,这对于评估心血管疾病风险至关重要. 这些发现有助于临床医生解释ApoB测试结果,以获得更好的患者护理.

科学领域:

临床生物化学临床生物化学
心血管疾病生物标志物心血管疾病生物标志物
人口健康研究人口健康研究

背景情况:

阿波蛋白B (ApoB) 是心血管疾病 (CVD) 风险的一个关键生物标志物.
传统的脂质测试可能无法完全捕捉心血管疾病风险,这突出了对ApoB评估的需要.
在韩国健康检查中,观察到ApoB测试的不足.

研究的目的:

确定韩国成年人正常传统脂质样本的ApoB的参考间隔.
将已确定的ApoB间隔与国际临床指南进行比较.
提供数据,以便在临床实践中更好地解释ApoB测试结果.

主要方法:

分析了264,105个传统的脂质测试套件,识别了464个ApoB测试.
在334个样本上使用参数 (平均±2 SD) 和非参数 (95百分位数) 方法确定ApoB参考间隔.
通过使用既定和国际截止值,根据性别比较ApoB患病率.

主要成果:

男性的参考间隔:46 - 134毫克/分升 (参数),50 - 131毫克/分升 (非参数).
女性的参考间隔:49 - 129毫克/分升 (参数),51 - 127毫克/分升 (非参数).
在使用性别特异或指南切断时,高ApoB患病率没有显著的基于性别的差异.

结论:

该研究为韩国人口提供了重要的ApoB参考间隔.
这些间隔将有助于临床医生和实验室准确解释ApoB测试.
提高ApoB测试的利用率可以改善韩国的心血管风险评估.

关键词:

在 ApoB ApoB 中.韩国韩国人韩国人韩国人亚脂蛋白B是一种非脂蛋白B.脱脂血症是什么情况脂质脂质是什么意思脂质脂质是什么意思参考时间间隔是参考时间间隔.

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