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超分辨率超声波成像,在糖尿病病的发展过程中,对糖类糖尿病脂肪大鼠的血管变化进行超分辨率超声波成像

Stinne Byrholdt Søgaard^1,2, Sofie Bech Andersen^1,2, Iman Taghavi³

¹Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

Diagnostics (Basel, Switzerland)

|October 28, 2023

概括

超分辨率超声波 (SRUS) 成像可以检测脏血管的早期变化,在临床症状出现之前潜在地预测糖尿病病 (DKD). 这种非侵入性技术对监测DKD进展具有前景.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
医疗成像医学成像
糖尿病学糖尿病学

背景情况:

糖尿病病 (DKD) 构成了重大的健康挑战,早期识别有风险的个体仍然很困难.
目前的临床方法缺乏预后准确性,无法有效预测DKD的发展.
评估脏微血管稀缺和血管扭曲性可以改善DKD预后和治疗启动.

研究的目的:

在2型糖尿病的临床前模型中研究脏血管密度和形度的变化.
评估超分辨率超声波 (SRUS) 成像用于预测DKD的潜力.
为了将SRUS发现与已确定的损伤标志物和ex vivo成像相关联.

主要方法:

一项临床前研究使用Zucker糖尿病脂肪 (ZDF) 鼠和瘦肉Zucker鼠作为对照.
超分辨率超声波 (SRUS) 成像,以评估体内微血管.
微计算机断层扫描 (μCT) 用于血管密度的体外验证.
测量白色素尿作为早期DKD的指标.

主要成果:

在22周的ZDF大鼠中,SRUS检测到皮质血管密度显著下降,与白尿增加相吻合.
早在12周就观察到血管密度下降的趋势,前面是白膜尿增加.
对血管密度的SRUS发现与ex vivoμCT测量结果有很好的相关性.
在ZDF大鼠中观察到血管扭曲性增加的趋势.

结论:

SRUS成像显示出作为DKD早期检测和预后的非侵入性工具的潜力.
该技术可以在明显的临床表现之前识别与DKD发展相关的微血管变化.
需要在大型动物和人类研究中进行进一步的验证,以确认SRUS在DKD管理中的实用性.

关键词:

慢性脏疾病慢性脏疾病诊断成像诊断成像的使用.造成的损伤.2 型糖尿病 2 型糖尿病超声波定位显微镜学超声波定位显微镜学

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