临床前正静态异常可能预测不同年龄组的血管硬的早期增加:试点研究
Victor N Dorogovtsev1, Dmitry S Yankevich1, Andrey E Gaydashev2
1Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|October 28, 2023
概括
临床前正静性低血压 (OH) 和高血压 (OHT) 随着年龄的增长而增加,即使在健康的成年人中也会影响血管硬. 这些早期迹象与较高的手臂脚脉冲波速度 (baPWV) 有关.
科学领域:
- 心脏病学 心脏病学
- 生理学 生理学 生理学
- 老年学是指老年学的学科.
背景情况:
- 临床正静性低血压 (OH) 和高血压 (OHT) 是动脉高血压 (AH) 和心血管疾病 (CVD) 的确立危险因素.
- 这些情况与血管硬性增加有关,但临床前形式仍然不明.
- 了解临床前的正静态异常对于早期心血管风险评估至关重要.
研究的目的:
- 在不同年龄组的临床健康成年人中调查临床前静态异常.
- 评估临床前静态形异常与血管硬度增加之间的关联.
- 为了确定与年龄相关的正统血压调节和血管功能的年龄差异.
主要方法:
- 专门设计的头向上倾斜测试,标准化为水静电柱高度,被用来检测临床前的正静电异常.
- 研究人员对临床健康的三组年龄组进行了检查:年龄在30岁以下,30-45岁,45岁以上.
- 血管硬度是用手臂脚脉冲波速率 (baPWV) 来测量的.
主要成果:
- 年轻的成年人 (年龄在30岁以下) 呈现出正静态正常血压 (ONT) 占主导地位,临床前OH或OHT病例很少.
- 在45岁以上的成年人中,与年轻人相比,ONT减少了两倍,临床前OH和OHT显著增加.
- 所有年龄组都表现出baPWV的静态增加,在返回卧卧姿势后正常化.
- 临床前OH和OHT患者的baPWV值明显高于ONT患者,尽管所有值都在正常年龄相关的范围内.
结论:
- 临床前正静性低血压和高血压在老年健康成年人中很普遍,并且与血管硬性增加有关.
- 年龄显著影响临床前正统性异常的患病率及其对血管功能的影响.
- 早期检测临床前静态形异常可能有助于识别患心血管疾病风险较高的个体.
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