相关实验视频

Updated: Jul 12, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

重金属与肠道微生物群的相互作用:对自闭症谱系障碍的影响

Yousef Tizabi¹, Samia Bennani², Nacer El Kouhen²

¹Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA.

|October 28, 2023

概括

暴露于和肠道微生物群的破坏可能导致自闭症谱系障碍 (ASD). 理解这种肠-大脑轴相互作用为ASD提供了潜在的治疗途径.

科学领域:

神经发育障碍神经发育障碍
环境毒理学环境毒理学
微生物学微生物学

背景情况:

自闭症谱系障碍 (ASD) 是一种神经发育状况,其特征是社会沟通缺陷和受限制的行为.
自闭症的确切病因仍然不完全理解,遗传学和环境因素都与此有关.
新兴研究强调了肠道微生物群失调和 (Pb) 暴露在ASD中的潜在作用.

研究的目的:

审查当前对自闭症谱系障碍 (ASD) 的理解.
探索肠道微生物群 (GM) 的作用及其与 (Pb) 在ASD中的相互作用.
讨论针对ASD肠-大脑轴的潜在治疗策略.

主要方法:

文献综述侧重于ASD,肠道微生物群和暴露.
对称为肠-大脑轴 (GBA) 的双向通信通道的分析.
强调Pb,GM和ASD病理生理学的相互作用.

主要成果:

(Pb) 是一种有毒金属,与不良健康结果有关,包括与ASD相关的认知和行为问题.
暴露于Pb可以对肠道微生物群 (GM) 产生负面影响,这对生理和心理功能至关重要.
肠-大脑轴 (GBA) 代表了GM-大脑相互作用的重要途径.

结论:

暴露,肠道微生物群扰乱和肠-大脑轴之间的相互作用是ASD的关键研究领域.
这种相互作用为自闭症谱系障碍的新型治疗干预提供了有希望的目标.
对Pb-GM相互作用的进一步研究可以阐明ASD机制,并为治疗开发提供信息.

关键词:

自闭症谱系障碍自闭症谱系障碍肠大脑轴肠大脑轴的毒性的毒性的毒性我们的微生物群.益生菌是一种益生菌.

更多相关视频

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Published on: August 18, 2023

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

The Periodic Table and Organismal Elements

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...