在早产婴儿中比较胆体积保证和压力调节体积控制模式
Şehribanu Işık1, Fuat Emre Canpolat1, Gülsüm Kadıoğlu Şimşek1
1Department of Neonatology, University of Health Sciences, Ankara City Hospital MH5, Çankaya, Ankara 06800, Turkey.
Children (Basel, Switzerland)
|October 28, 2023
概括
与压力调节体积控制 (PRVC) 相比,早产新生儿的胆脉体积保证 (VG) 通风显示出较低的峰值吸气压力和更好的氧和. 这两种模式对早产婴儿都是安全的.
科学领域:
- 新生儿重症监护中心
- 机械通风机械通风机械通风
- 呼吸系统支持 呼吸系统支持
背景情况:
- 过早出生的新生儿通常需要机械通风,因为呼吸系统不成熟.
- 通用电气Carescape R860通风机提供多种模式,包括双级体积保证 (VG) 和压力调节体积控制 (PRVC).
- 关于这些特定模式在极度早产婴儿的安全性和有效性的比较数据有限.
研究的目的:
- 为了比较GE Carescape R860通风机的双级体积保证 (VG) 和压力调节体积控制 (PRVC) 模式.
- 评估这些通风模式在早产儿的安全性和可行性.
- 评估与每个通风模式相关的早期临床结果.
主要方法:
- 一项随机交叉研究,涉及28名早产新生儿 (<30周妊娠年龄).
- 婴儿在一种模式 (双级VG或PRVC) 中接受了2小时的通风,然后在另一种模式中接受了2小时的通风.
- 呼吸器参数 (例如,峰值吸气压),生命体征 (心率,氧和度) 和血液气体值都被监测.
主要成果:
- 与PRVC模式 (14 cmH2O) 相比,双层VG模式 (13 cmH2O) 中的平均峰值吸气压明显较低 (p=0.008).
- 胆道VG通风导致平均心率下降 (149到140/分钟,p=0.001) 和氧和增加 (91%到94%,p=0.01).
- 没有报告任何重大不良事件,这表明这两种模式的安全性.
结论:
- 在GE Carescape R860呼吸机上的双级VG和PRVC模式对于早产婴儿来说都是安全的和可行的.
- 双层VG模式表现出更有利的早期临床发现,包括较低的PIP和改善的氧化.
- 需要对更大的队列进行进一步的研究,并与其他模式进行比较,以巩固证据.
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