儿科COVID-19结果:血液学参数,死亡率和住院时间
Abdulrahman Alshalani1, Badi A Alotaibi2,3, Jehad A Aldali4
1Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Children (Basel, Switzerland)
|October 28, 2023
概括
年龄是儿童COVID-19死亡率的关键因素,老年儿童的死亡率较低. 血小板计数和凝血测量等血液学参数与儿童的COVID-19状态,年龄和性别存在复杂的相关性.
科学领域:
- 儿科血液学 儿科血液学
- 传染病流行病学 传染病流行病学
- 临床生物化学 临床生物化学
背景情况:
- COVID-19 流行病对全球医疗保健系统产生了重大影响,促使人们对影响患者结果的因素进行研究.
- 了解儿科COVID-19需要调查血液学标志物和临床结果之间的相互作用.
研究的目的:
- 检查关键血液学参数,住院时间 (LOS) 和儿科COVID-19患者的死亡率之间的关系.
- 确定COVID-19儿童死亡率和LOS的独立预测因素.
主要方法:
- 多变量回归模型用于分析独立变量 (COVID-19状态,年龄,性别) 和依赖变量 (死亡率,LOS,凝血参数,白细胞计数,红细胞参数) 之间的关系.
- 评估系数的统计学意义,以确定独立变量对结果的影响.
主要成果:
- 年龄是死亡率的重要预测因素,每个年龄组的死亡率都在下降. 无论是COVID-19状态还是年龄,都与LOS相反相关,这表明儿童的疾病程度较轻.
- 血小板数量随着年龄的增长和男性的减少. 在COVID-19状态,年龄,性别和凝血测量 (原血红素时间,D-二次数) 之间发现了显著的相关性.
- COVID-19阳性患者的白细胞 (WBC) 数量较低,而男性的红细胞 (RBC) 数量较高. 观察到与红细胞分布宽度,平均体质体积和平均体质血红蛋白的相关性.
结论:
- 年龄是儿童COVID-19病例死亡率的关键决定因素.
- 血液学参数,包括血小板计数和凝血标记,与儿童的COVID-19状态,年龄和性别呈现复杂的相互作用.
- 该研究强调了年龄的重要性,并提供了对儿科COVID-19血液学变异的见解,强调了疾病结果的复杂性.
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