一个实用更新关于儿科埃索诺菲尔食道炎的实用更新
Martina Votto1,2, Maria De Filippo1,2, Silvia Caimmi2
1Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Children (Basel, Switzerland)
|October 28, 2023
概括
性食道炎 (EoE) 是影响食道的日益严重的过敏状况,主要是由食物过敏原引发的. 目前的治疗方法包括药物治疗,饮食改变和内镜监测,新生物药物正在出现.
科学领域:
- 胃肠病学 胃肠病学
- 过敏和免疫学 过敏和免疫学
- 儿科 儿科 儿科
背景情况:
- 乙性食管炎 (EoE) 是一种未知原因的新出现的亚托皮性疾病,其特征是2型炎症,并由食物过敏原引发.
- 缺陷的食道屏障功能有助于食物过敏原刺激炎症细胞,导致EoE.
- 儿童和青少年的临床表现各不相同,包括食问题,吐,发育不良,疼痛,消化不良和食物受损.
研究的目的:
- 审查当前对EoE病原,临床和分子异质性以及治疗方法的理解.
- 强调实现深度缓解 (临床,内镜,组织学) 和预防食道纤维化的重要性.
- 讨论识别不同的EoE表型和内型以及新兴疗法的作用.
主要方法:
- 诊断和监测依赖于上胃肠内镜.
- 治疗策略包括质子抑制剂,局部类固醇 (fluticasone,budesonide) 和消除食物的饮食.
- 最近的进展涉及了解EoE异质性和评估新的治疗方法,包括Dupilumab等生物药物.
主要成果:
- 临床,分子,内镜和组织学特征影响EoE演变和治疗反应.
- 已经确定了不同的EoE表型和内型,反映了疾病的复杂性.
- 杜皮卢马布是第一个批准的生物疗法,用于青少年和成年人的活跃EoE.
结论:
- 公开教育管理需要一个长期的,多学科的方法,定期跟进.
- 了解EoE异质性对于个性化治疗策略至关重要.
- 对包括生物药物在内的新疗法进行持续的研究对于改善患者的治疗结果至关重要.
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
168
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
168
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Esophageal Strictures-II: Clinical Features and Management
78
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
78
Asthma: Pathogenesis and Management
421
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
421
Gastroesophageal Reflux Disease II: Clinical Features and Management
93
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
93
Cystic Fibrosis: Management
173
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
173


