一项试点可行性研究评估了早期行为干预和普罗兰诺洛尔对自闭症谱系障碍 (ASD) 的联合影响
Kathy Hirst1, Rachel M Zamzow2, Janine P Stichter1
1Thompson Center for Autism and Neurodevelopment, University of Missouri, Columbia, MO 65211, USA.
Children (Basel, Switzerland)
|October 28, 2023
概括
这项研究探讨了将普拉诺洛尔与自闭症谱系障碍 (ASD) 的早期密集行为干预 (EIBI) 结合起来. 虽然由于样本大小而不能得出结论,但这种组合似乎是可行的,副作用很少.
科学领域:
- 神经发育障碍 神经发育障碍
- 药理干预药理干预
- 行为治疗是一种行为疗法.
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会沟通缺陷和重复性行为.
- 早期强化行为干预 (EIBI) 对ASD有效,但增强策略研究不足.
- 研究ASD的综合药理和行为方法对于推进治疗至关重要.
研究的目的:
- 评估在患有自闭症的儿童中将普拉诺洛尔与EIBI结合使用的可行性.
- 在这种情况下,检查兰醇的安全性和耐受性.
- 收集用于更大的疗效试验的初步数据.
主要方法:
- 一个双盲,安慰剂控制的可行性试验.
- 9名患有自闭症的儿童 (3-10岁) 接受了EIBI,并随机分配给propranolol或安慰剂12周.
- 在基线,6周和12周使用GSOM-2和SRS-2评估了社会互动结果.
主要成果:
- 五名参与者完成了为期12周的研究.
- 样本大小不足以确定治疗疗效.
- 普罗普拉诺洛尔 (propranolol) 一般耐受良好,副作用不常见.
结论:
- 在ASD治疗中,将普拉诺洛尔与EIBI结合使用似乎是可行的和安全的.
- 需要进行更大的临床试验来评估这种综合方法的疗效.
- 这项研究有助于了解未来ASD干预研究的可行性.
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