加快的衰老和早产儿的生命历程
Audrey Bousquet1, Keia Sanderson2, T Michael O'Shea3
1Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Children (Basel, Switzerland)
|October 28, 2023
概括
过早出生的人面临更短的寿命和更高的慢性疾病风险,可能是由于加速衰老. 本综述探讨了早产个体的衰老生物标志物和保护因素.
科学领域:
- 生殖医学 生殖医学
- 老年学是指老年学的学科.
- 发展生物学 发展生物学
背景情况:
- 过早出生的人的寿命缩短,慢性疾病的发病率增加,相比于过期出生的人.
- 新出现的证据将早产和低出生体重与加速衰老的生理和细胞标志物联系起来.
- 加速衰老对早产儿慢性疾病和死亡风险升高的贡献尚不清楚.
研究的目的:
- 审查在早产的成年人中观察到的加速衰老表型.
- 检查与加速衰老相关的生物途径.
- 为了确定生物标志物和弹性因素,可以减轻该人口的加速衰老.
主要方法:
- 关于早产,加快衰老和相关健康结果的研究文献综述.
- 分析衰老的生理和细胞生物标志物.
- 药理和非药理干预的探索.
主要成果:
- 过早分娩与加速衰老的表型有关.
- 特定的生物学途径有助于早产个体加速衰老.
- 已经确定了加速衰老的生物标志物和潜在的缓冲因素.
结论:
- 加速衰老对早产的个人来说是一个重大问题,这可能解释了他们患慢性疾病和死亡风险的增加.
- 了解这些衰老途径和保护因素对于开发有针对性的干预措施至关重要.
- 需要进一步的研究,以充分阐明早产人口加速衰老的机制和有效的缓解策略.
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Aging
59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59
Nature and Nurture
20.5K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K


