饮食中的迪卡诺酸与冠状动脉疾病之间的关系:基于人口的横截面研究
Zhijian Wu1, Weichang Yang2, Meng Li1
1Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Nutrients
|October 28, 2023
概括
饮食中摄入的迪卡诺酸 (DDA) 与较低的冠状动脉疾病 (CAD) 患病率有关. 较高的DDA消费可能会降低CAD风险,特别是在男性和非西班牙裔白人中.
科学领域:
- 营养科学 营养科学
- 心血管研究研究心血管研究
- 流行病学 流行病学
背景情况:
- 冠状动脉疾病 (CAD) 对健康和经济造成重大负担.
- 迪卡诺酸的生物作用和CAD的发病有共同的途径.
- 关于decanoic acid和CAD之间的直接关系的研究有限.
研究的目的:
- 调查饮食中摄入的酸 (DDA) 与CAD患病率之间的关联.
- 探索人口因素对这种关联的潜在改变影响.
主要方法:
- 分析了34186名参与国家健康和营养检查调查 (NHANES) (2003-2018) 的数据.
- 利用加权多变量逻辑回归,通用总和模型和光滑曲线来评估DDA-CAD关系.
- 进行了分层分析和相互作用测试,以确定潜在的修饰剂.
主要成果:
- 在DDA摄入量和CAD患病率之间观察到负相关性.
- 每增加1g/d的DDA与21%的CAD患病率降低有关 (或0.79).
- 在经过统计转换和在男性和非西班牙裔白人的子组分析中,这种关联仍然显著.
结论:
- 饮食中摄入的酸 (DDA) 与冠状动脉疾病 (CAD) 患病率相反相关.
- 性别和种族似乎是DDA-CAD关系的重要修饰因素.
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