维生素D缺乏对败血症的影响
Hyeri Seok1, Jooyun Kim1, Won Suk Choi1
1Division of Infectious Diseases, Department of Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea.
Nutrients
|October 28, 2023
概括
严重的维生素D缺乏症显著增加了败血症患者的死亡率. 这强调了评估毒症老年人维生素D水平的重要性,以获得更好的结果.
科学领域:
- 关键护理医学 关键护理医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染的反应失调引起的.
- 维生素D缺乏很普遍,特别是在老年人群中,可能会影响免疫反应.
- 维生素D缺乏对败血症预后的影响仍然不完全理解.
研究的目的:
- 为了研究维生素D缺乏和毒症患者的死亡率之间的关联.
- 为了确定严重的维生素D缺乏是否独立地预测了败血症的不良结果.
主要方法:
- 一项前性队列研究,涉及129名败血症患者 (平均年龄74岁,SOFA中位数7).
- 评估维生素D水平,并将其分为缺乏和严重缺乏的组.
- 统计分析包括调整后的危险比率 (aHR) 和卡普兰-梅尔生存分析.
主要成果:
- 维生素D水平的中位数为13 ng/mL;96名患者缺乏维生素D,62名患者严重缺乏维生素D.
- 严重的维生素D缺乏与14天 (aHR 2.57),28天 (aHR 2.28) 和住院死亡率 (aHR 2.11) 的显著增加有关.
- 卡普兰-梅尔分析显示,严重缺陷组的死亡率高于非缺陷组.
结论:
- 严重的维生素D缺乏是败血症患者预后不佳的独立风险因素.
- 评估毒症患者的维生素D状况,特别是在老龄化社会,可能具有临床相关性.
- 需要进一步的研究来探索维生素D补充剂在改善败血症结果方面的潜在益处.
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