精神分裂症中的肠-大脑轴:肠道微生物组和SCFA生产的影响
Songhyun Ju1,2,3, Yoonhwa Shin1,2,3, Sunhee Han1,2,3
1Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Nutrients
|October 28, 2023
概括
肠道微生物组及其副产品,短链脂肪酸 (SCFA),可能会影响精神分裂症. 理解肠-大脑轴为这种精神疾病提供了新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症是一种严重的精神疾病,影响1%的人口,复杂的原因包括遗传和环境因素.
- 新兴研究将怀孕期间的母亲因素和肠-大脑轴与精神分裂症风险联系起来.
- 肠道微生物组在生理学,免疫和中枢神经系统功能中发挥着至关重要的作用,干扰可能会影响心理健康.
研究的目的:
- 探索短链脂肪酸 (SCFA),肠道微生物群和精神分裂症之间的关系.
- 在精神分裂症的背景下,深入了解肠-大脑轴.
- 阐明对未来研究和精神分裂症治疗策略的影响.
主要方法:
- 这是一篇综述性文章,综合了有关肠道微生物组,SCFA和精神分裂症的现有研究.
- 该审查审查了肠道微生物代谢产物,特别是SCFA在影响中枢神经系统活动中的作用.
- 它探讨了肠道微生物群失调如何可能导致与精神分裂症相关的神经递质失调.
主要成果:
- 肠道微生物产生SCFA,可以穿越血脑屏障并调节中枢神经系统活动,包括微质和细胞因子反应.
- 肠道微生物产生的神经递质的失调与精神分裂症等中枢神经系统疾病有关.
- 肠道微生物群的干扰,受饮食,药物和压力的影响,可以对中枢神经系统功能和心理健康产生重大影响.
结论:
- 肠道微生物组和SCFA代表了肠-大脑轴影响精神分裂症的潜在联系.
- 对肠-大脑轴的进一步研究对于开发新型精神分裂症治疗方法至关重要.
- 准肠道微生物群可能为管理精神分裂症和其他中枢神经系统疾病提供新的途径.
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