乳清蛋白水解剂具有抗炎作用,可通过微生物组恢复缓解德克斯硫酸 (DSS) 诱导的结肠炎
Wenrong Zou1, Zixin Fu1, Xiaohong Guo2
1Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Nutrients
|October 28, 2023
概括
乳清蛋白水解剂 (WPH) 通过减少炎症和恢复肠道健康,有效预防结肠炎. 这种饮食干预措施对控制炎症性肠道疾病充满希望.
科学领域:
- 胃肠道学和免疫学
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 炎症性肠道疾病,如大肠炎,对健康构成重大挑战.
- 乳清蛋白水解剂 (WPH) 呈现出各种生物活性.
- 了解WPH在治疗大肠炎方面的潜力至关重要.
研究的目的:
- 调查WPH对小鼠中酸 (DSS) 诱导的大肠炎的预防作用.
- 阐明WPH对大肠炎的保护作用背后的机制.
主要方法:
- 在C57BL/6J小鼠中使用DSS诱导大肠炎.
- 在37天的时间里,WPH的管理.
- 评估临床症状,结肠粘膜完整性,炎症标志物 (TNF-α,IL-6,IL-1β),短链脂肪酸 (SCFA),肠道微生物组组成和MHC I类通路.
主要成果:
- 干预WPH延迟了结肠炎的发展,并显著减少了体重减轻,结肠炎症和炎症因素.
- WPH上调了SCFA分泌,恢复了肠道微生物组的平衡,特别是增加了Muribaculaceae的norank和减少了Romboutsia和Enterobacter.
- WPH的保护作用与微生物组的恢复和MHC I类途径的调节有关.
结论:
- 在小鼠中,WPH表现出显著的抗炎活性和对DSS诱导的大肠炎的保护作用.
- 通过调节肠道微生物群和炎症通路,WPH可以改善结肠炎.
- WPH为结肠炎管理提供了一个有前途的治疗策略.
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