25OH维生素D在36周前过量,经过年龄校正,是否是支气管肺形或死亡的独立危险因素?
Sophie Laborie1, Maxime Bonjour2,3, Justine Bacchetta3,4,5
1Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.
Nutrients
|October 28, 2023
概括
在早产婴儿中,高维生素D水平 (≥120nmol/L) 与支气管肺张力症 (BPD) 或死亡风险的增加无关. 这项研究表明,过量的25-基维生素D在这个脆弱人群中不会对BPD造成重大风险.
科学领域:
- 新生儿医学 新生儿医学
- 儿科肺病学 儿科肺病学
- 营养科学 营养科学
背景情况:
- 低25-氧维生素D (25(OH) D) 是早产婴儿支气管肺功能障碍 (BPD) 的危险因素.
- 以前的研究表明,关于维生素D补充剂和BPD的结果是不同的.
- 动物模型表明,缺乏和多余的维生素D都会损害肺部发育.
研究的目的:
- 调查高水平的25-OH-D (≥120nmol/L) 是否与早产婴儿患 BPD 或死亡的风险增加有关.
- 检查过多的维生素D与极度早产新生儿的不良结果之间的关系.
- 澄清维生素D在BPD发展中的作用.
主要方法:
- 回顾性单中心队列研究,对出生在<31周妊娠年龄的婴儿进行.
- 包括在内的婴儿在经校正的年龄小于36周时测定了25...OH) D水平,并且没有水平低于50nmol/L.
- 通过逻辑回归分析了175名婴儿,评估了25...OH) D水平,BPD和死亡率.
主要成果:
- 患有BPD或死亡的婴儿的出生体重和妊娠年龄较低.
- 在患有BPD或死亡的婴儿和没有BPD/死亡的婴儿之间,25...OH) D水平≥120nmol/L的频率相似 (50.5%对43.9%).
- 后勤回归确定了较低的体重和妊娠年龄,但不过度的25(OH) D,作为BPD或死亡的重要风险因素.
结论:
- 这项研究没有发现过高的25OH) D水平 (≥120nmol/L) 与早产婴儿中 BPD 或死亡风险之间的显著关联.
- 低出生体重和妊娠年龄仍然是BPD或死亡的重要风险因素.
- 可能需要进一步的研究,以充分阐明最佳的维生素D范围,以预防早产婴儿的BPD.
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