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Limosilactobacillus vaginalis表现出双生效:婴儿前生物补充的新型后生物战略
Barbara Giordani1, Carola Parolin1, Angela Abruzzo1
1Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Nutrients
|October 28, 2023
概括
被热杀死的Limosilactobacillus vaginalis BC17,一种阴道微生物衍生物,促进婴儿有益的Bifidobacterium生长. 这种后生物质是安全的,有助于肠道微生物群的发展,可能预防婴儿疾病.
科学领域:
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
- 后生物学的后生物学.
背景情况:
- 婴儿肠道微生物群对于健康和长期健康至关重要.
- 剖腹产和配方养导致婴儿的肠道微生物多样性较低,增加疾病风险.
- 用阴道微生物或衍生物 (后生物) 补充可以促进健康的肠道微生物群发育.
研究的目的:
- 为了研究热杀死的Limosilactobacillus vaginalis BC17的双发性活性.
- 评估婴儿使用L. vaginalis BC17的安全性.
- 评估热杀死L. Vaginalis BC17作为婴儿肠道健康后生物的潜力.
主要方法:
- 使用纳米孔技术对L. vaginalis BC17的全基因组测序.
- 最低抑制度 (MIC) 测试对抗生素敏感性的测试.
- 在体外评估热杀死BC17对Bifidobacterium spp.的影响. 增长,生物膜形成和病原体抑制.
- 用于婴儿口服的太阳花油悬浮中的热杀死BC17的配方,并测试其稳定性和功能性质.
主要成果:
- 在L. vaginalis BC17基因组分析中,没有发现抗生素耐药性基因或毒性因子,证实了安全性.
- 热杀死的BC17显著增强了浮游生物的生长和Bifidobacterium spp.生物膜的形成.
- 经过热杀死的BC17显示出抗菌和抗生物膜活性,对抗阳性和阴性病原体.
- 该配方产品表现出最佳的技术和功能特性,包括在酸性预消化后的稳定性.
结论:
- 经热杀死的L. vaginalis BC17是一种安全有效的后生菌,具有双生菌性质.
- 这种后生物可以刺激有益的Bifidobacterium生长和婴儿的生物膜形成.
- 它还表现出对病原体的抗微生物作用,支持健康的婴儿肠道微生物群的发展.
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