基于营养素的黑色素瘤治疗方法:预防和治疗见解
Yucheng Dong1, Jiaxin Wei2, Fan Yang3
1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Nutrients
|October 28, 2023
概括
维生素D和食纤维等营养成分在改善黑色素瘤预后和治疗结果方面表现有前途. 需要进一步的研究来澄清大多数营养素对黑色素瘤风险和预防的影响.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 皮肤病学 皮肤病学
背景情况:
- 黑色素瘤是一种危险的皮肤癌,在预防和治疗方面存在持续的挑战.
- 了解营养素和黑色素瘤之间的关系对于开发新策略至关重要.
- 现有的研究已经探索了各种营养素,但需要对它们对黑色素瘤预后和治疗的影响进行全面的概述.
研究的目的:
- 为预防黑色素瘤和辅助治疗提供基于营养的方法提供了新的视角.
- 详细说明特定营养素对黑色素瘤预后和治疗结果的影响.
- 探索营养素影响黑色素瘤进展,免疫反应和生理过程的机制.
主要方法:
- 关于营养素和黑色素瘤的现有科学文献的综述.
- 检查各种营养素,包括抗氧化剂 (维生素A,D,C,E,,咖啡因),多不和脂肪酸和黄.
- 对研究营养素对黑色素瘤风险,免疫反应,血管新生和细胞生长的影响进行分析.
主要成果:
- 咖啡因显示出对黑色素瘤的最有前途的保护作用,得到了多项队列研究的支持.
- 在临床前研究中,维生素D和显示出免疫调节作用,多具有抗血管性潜力,而黄类药物抑制了细胞生长.
- 维生素D可能会降低术后复发率,高纤维饮食可以提高黑色素瘤患者的免疫治疗效率.
结论:
- 虽然许多营养素对黑色素瘤风险的影响尚不清楚,但维生素D和食纤维显示出改善预后和治疗结果的潜力.
- 营养素作用的临床前证据是强有力的,但基于人类的研究是有限的,限制了临床应用.
- 个性化,涉及各种医疗专业人员的跨学科方法对于优化黑色素瘤治疗策略至关重要.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K


