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增加可溶性p-选择素水平预测了更高的外周动脉样硬化斑块进展
Philip Sommer1, Michael Schreinlechner1, Maria Noflatscher1
1Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria.
Journal of clinical medicine
|October 28, 2023
概括
增加可溶性P-选择素 (sP-选择素) 水平预测了较大的动脉样硬化斑块的进展. 连续测量sP-selectin提供了一个简单的生物标志物,用于监测外周动脉样硬化发展.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- P-选择素是一种粘附分子,参与动脉样硬化病变的发生.
- 溶性P-选择素 (sP-选择素) 是内皮细胞和血小板激活的标志物.
- 周围动脉样硬化进展是一个重要的临床问题.
研究的目的:
- 评估sP-选择因对外周动脉样硬化进展的预测价值.
- 评估sP-选择素水平与动脉样硬化斑块体积变化之间的关联.
- 为了确定sP-selectin是否可以提高现有的心血管风险得分.
主要方法:
- 在443名患有心血管疾病或风险因素的患者中进行了观察性单中心队列研究.
- 4年内每年3D超声波评估动脉和大腿动脉斑块体积.
- 连续的血sP-selectin测量和生长曲线建模以分析关联.
主要成果:
- 1 SD增加的sP-选择素与斑块体积增加46.09 mm3相关 (p < 0.001).
- 在sP-selectin的变化改善了ESC-SCORE的预测值 (AUC 0.75).
- 增加的sP-选择素水平与明显更高的斑块进展 (202 mm3 vs 110 mm3) 有关.
结论:
- 升高的sP-选择素水平预测了动脉样硬化斑块进展的增加.
- 连续测量sP-selectin作为外周动脉样硬化的一个可访问的生物标志物.
- sP-选择因具有改善心血管疾病风险分层的潜力.
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