多囊卵巢综合征中的抑郁症:系统性审查和元分析
Paweł Dybciak1, Dorota Raczkiewicz2, Ewa Humeniuk3
1Centre of Postgraduate Medical Education, Marymoncka Street 99/103, 01-813 Warsaw, Poland.
Journal of clinical medicine
|October 28, 2023
概括
患有多囊性卵巢综合征 (PCOS) 的女性患抑郁症的风险明显更高. 这次元分析发现,与健康个体相比,抑郁症的患病率为31%,患病率是健康个体的2.5倍以上.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响生育年龄的女性.
- 抑郁症是PCOS相关的严重并发症,影响生活质量.
- 医院焦虑和抑郁量表 (HADS) 是评估抑郁症的广泛使用的工具.
研究的目的:
- 为了确定患有PCOS的女性中抑郁症的患病率.
- 分析PCOS患者的平均抑郁评分及其标准化差异.
- 与对照人群相比,量化PCOS患者抑郁症的概率.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Scopus,ClinicalTrials.gov,Google) 进行了系统的文献搜索,直到2023年1月.
- 分析包括了来自19项研究的数据,其中包括4002名被诊断患有PCOS的绝经前成年女性.
- 医院焦虑和抑郁量表 (HADS) 用于评估抑郁症的流行率和得分.
主要成果:
- 在患有PCOS的女性中,抑郁症的平均患病率为31% (I2 = 93%,p < 0.001).
- 平均HADS抑郁评分为6.31 (I2 = 93%,p < 0.001),标准化平均差异为0.421.
- 与健康女性相比,PCOS患者患抑郁症的几率是健康女性的2.5倍以上 (RR:2.58,CI [1.38-4.85],I2 = 90%,p < 0.001).
结论:
- 患有PCOS的女性患有抑郁症状的风险显著增加.
- 这些发现强调了PCOS患者抑郁症查和管理的重要性.
- 在PCOS中精神健康并发症的早期干预对于改善患者结果至关重要.
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