骨关节炎中的自身感受和机制感受器:一个系统的文献综述
Francesca Salamanna1, Silvio Caravelli2, Laura Marchese1
1Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
Journal of clinical medicine
|October 28, 2023
概括
骨关节炎 (OA) 患者表现出自身感受受损失,特别是在膝盖后十字带 (PCL),可能是由于机械感受器的变化. 需要进一步的研究来澄清自身感受在OA管理中的作用.
科学领域:
- 整形外科 整形外科 整形外科
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
背景情况:
- 骨关节炎 (OA) 是一种常见的慢性疾病,导致严重的疼痛和功能障碍.
- 亲感,身体位置的感觉,对于关节的稳定性和功能至关重要.
研究的目的:
- 系统地审查患有骨关节炎的患者自身感受和相关机械感受器的变化.
- 分析膝关节疾病,特别是后十字带 (PCL) 和软骨病变对自身感受的影响.
主要方法:
- 在PubMed,Web of Science和Scopus (2013年9月至2023年9月) 进行了系统的文献搜索,遵循PRISMA指南.
- 包括的研究使用ROBINS-I工具评估了偏差风险.
- 使用描述性方法总结了14项临床研究的发现.
主要成果:
- 骨关节炎患者,特别是膝关节PCL患者,表现出受损的自感准确性.
- 机械受体 (Ruffini,Pacini,Golgi Mazzoni体质) 的变化被认为是减少自身感受的原因.
- 膝关节软骨病变显著影响自身感受,这是动态稳定计发现的证据.
结论:
- 在OA中,自身感知精度很重要,特别是在膝关节PCL和软骨方面.
- 在OA中,自身感受和机械感受器的确切作用需要进一步研究.
- 未来的研究应该探索年龄/性别差异和非膝关节OA关节,以提高临床结果.
相关概念视频
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Knee Joint
1.9K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.9K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K


