冠状动脉疾病患者的分层通过循环细胞因子概况:试点研究
Concetta Iside1, Ornella Affinito1, Bruna Punzo1
1IRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, Italy.
Journal of clinical medicine
|October 28, 2023
概括
像IL6,CCL2_MCP1和FLT1这样的血清细胞因子显示出诊断冠状动脉疾病 (CAD) 的潜力. 升高的水平与疾病严重程度相关,可以帮助非侵入性地分层患者的风险.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 冠状动脉疾病 (CAD) 是一种由动脉样硬化驱动的慢性炎症状况.
- 内皮功能障碍通过释放促炎性细胞因子引发动脉样硬化,从而加剧血管炎症.
- 血清细胞因子水平与CAD严重程度之间的确切关系需要进一步阐明.
研究的目的:
- 调查血清细胞因子度与冠状动脉疾病 (CAD) 严重程度之间的相关性.
- 评估特定细胞因子在识别CAD中的诊断和预测潜力.
- 探索血清细胞因子在疑似CAD患者的非侵入性风险分层中的实用性.
主要方法:
- 来自75名疑似患有CAD的患者的血清样本使用基于多重珠的免疫试验进行了分析.
- 使用流量细胞计技术同时量化11种细胞因子.
- 使用统计分析来比较CAD患者和健康受试者之间的细胞因子水平,并将其与疾病严重程度相关联.
主要成果:
- 与健康个体相比,CAD患者的sRAGE,CCL2_MCP1,FLT1和IL6水平显著增加.
- 观察到细胞因子水平 (sCD40L,FLT1,sRAGE,CCL2-MCP1,TNFα) 的增加趋势,加剧了CAD的严重程度.
- 升高的IL6水平预测非阻塞性CAD,而增加的CCL2_MCP1或FLT1预测阻塞性CAD.
结论:
- 血清细胞因子概况,包括IL6,CCL2_MCP1和FLT1,与CAD的存在和严重程度有关.
- 这些细胞因子显示出作为CAD诊断和风险分层的非侵入性生物标志物的潜力.
- 结合多个血清细胞因子可能会提高怀疑CAD的患者的非侵入性风险评估的准确性.
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