分子瘤板 (MTB):从标准疗法到精准医学
Zelmira Ballatore1, Francesco Bozzi2, Sara Cardea2
1Department of Medical Oncology, AOU delle Marche, 60126 Ancona, Italy.
Journal of clinical medicine
|October 28, 2023
概括
分子瘤委员会 (MTB) 通过分析瘤基因组资料,提供个性化癌症护理. 这种多学科的方法有助于确定耐药转移性疾病患者的向治疗方法,改善治疗选择.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 个性化医疗是个性化的医疗.
背景情况:
- 转移性癌症通常由于瘤异质性和复杂的基因组景观而表现出耐药性.
- 个性化诊断治疗策略正在出现,将临床史和分子生物学整合到传统组织学之外.
- 分子造型研究个体瘤基因组景观,以指导针对性的治疗方法.
研究的目的:
- 评估分子瘤委员会 (MTB) 在为耐药癌症患者选择个性化,有针对性的治疗策略方面的实用性.
- 在多学科委员会设置中评估基因组分析的可行性和影响.
主要方法:
- 在区域癌症中心建立一个由瘤学家,分子生物学家和遗传学家组成的MTB.
- 通过远程医疗推送临床病例,使用商业测试 (FoundationOne CDx,液体CDx) 和当地下一代测序 (NGS) 面板进行分子分析.
- 遗传突变的多学科评估和提供医学建议.
主要成果:
- 在2年的时间里,有97名患者被转诊,其中90人被批准进行基因组分析.
- 在分析的病例中,有5% (5/88) 的病例显示出可操作的驱动突变,导致立即注册有针对性的治疗.
- 建议对三名患者进行非标签治疗.
结论:
- 分子瘤板是实现瘤学中精确医疗目标的有效工具.
- 在像MTB这样的多学科团队中整合基于NGS的分析可以增强个性化护理.
- 未来实施基因组分析对优化治疗选择和患者管理至关重要.
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