不典型的等级连接被逐步的功能连接在衰老中揭示出来
Hechun Li1,2, Hongru Shi1,2, Sisi Jiang1,3
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Bioengineering (Basel, Switzerland)
|October 28, 2023
概括
老龄化改变了大脑的连接性,将焦点从默认模式网络转移到感官运动网络. 这种大脑重新配置与分子变化有关,并影响执行功能等认知功能.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 脑部成像 脑部成像
背景情况:
- 层次的功能结构对大脑功能至关重要.
- 衰老与大脑结构和功能的变化有关.
- 了解这些变化及其与其他因素的联系至关重要.
研究的目的:
- 为了研究老龄化如何影响大脑的层次功能结构.
- 探索功能结构和分子,微血管和认知特征中与年龄相关的变化之间的关系.
主要方法:
- 利用了老年人和年轻人的休息状态功能磁共振成像 (fMRI) 数据.
- 采用基于图形理论的分析,称为步骤功能连接 (SFC).
- 进行相关性和调解分析,将SFC模式与分子,微血管和认知数据联系起来.
主要成果:
- 衰老导致了层次功能结构的转变,模式汇聚到主要的感官-运动网络 (PSN) 而不是默认模式网络 (DMN).
- 随着年龄的增长,DMN中的逐步功能连接 (SFC) 减少,PSN中的增加.
- 改变的SFC模式与多巴胺和血清激素水平相关,微血管特征较差,执行功能较低.
结论:
- 衰老重新配置大脑枢纽系统,将主导权从DMN转移到PSN.
- 这些与年龄相关的功能性大脑变化与分子 (多巴胺,血清素) 和微血管因素有关.
- 微血管健康和功能连接性相互作用,影响衰老中的执行功能.
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