基因相关性作为1年后减肥手术结果的预测因素
Panayotis K Thanos1, Colin Hanna1, Abrianna Mihalkovic1,2
1Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biosciences, University at Buffalo, Buffalo, NY 14203, USA.
Biomedicines
|October 28, 2023
概括
遗传风险评估,包括遗传上风险严重性 (GARS) 评分和OPRM1和DRD2等特定基因多态性,可以预测腹手术患者的减肥结果. 更高的遗传上风险可能与手术后一年更好的减肥结果相关.
科学领域:
- 遗传学 是一个遗传学.
- 腹部外科 腹部外科
- 肥胖问题研究研究
背景情况:
- 减肥手术是严重肥胖症的关键干预措施.
- 预测手术后减肥结果仍然是一个挑战.
- 遗传因素可能会影响成和奖励途径,影响体重管理.
研究的目的:
- 调查减肥手术后一年体重减轻参数遗传风险评估的预测价值.
- 分析遗传多态 (OPRM1,DRD2) 和减肥之间的相关性.
- 评估遗传上风险严重性 (GARS) 评分和减肥结果之间的关系.
主要方法:
- 接受减肥手术的30名患者被评估为GARS,包括神经遗传多态.
- 在手术前收集遗传和心理社会数据.
- 分析了一年后遗传数据,心理社会评分和减肥指标 (体重,BMI,EWL%) 之间的相关性.
主要成果:
- OPRM1 (rs1799971) 多态性与1年体重和BMI负相关.
- DRD2风险等位基因 (rs1800497) 与较低的BMI,但较高的体重减轻和%EWL.相关.
- 总体GARS分数与%EWL,∆体重和∆BMI正相关.
- 食物渴望问卷 (FCQ) 的得分与%EWL和∆Weight.负相关.
结论:
- 遗传上风险,特别是涉及DRD2多态,可能预测更好的反应减肥手术减肥治疗.
- 遗传风险评估可以提供对个体患者对体重管理干预措施的反应的见解.
- 研究结果表明,在改善基于遗传倾向的患者对体重管理态度方面,有潜在的临床应用.
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