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关于生物打印皮肤替代品治疗伤口的现状的观点

Celena A Sörgel¹, Aijia Cai¹, Rafael Schmid¹

¹Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

|October 28, 2023

概括

生物打印为大规模的皮肤缺陷修复提供了一个有希望的替代方案,当自身移植不够时. 这项技术使生物制造的皮肤替代品能够恢复皮肤功能并加速伤口愈合.

科学领域:

再生医学是一种再生医学.
组织工程是组织工程.
生物技术是生物技术.

背景情况:

人体皮肤容易受到辐射,极端温度和化学创伤的损伤,导致严重的缺陷.
自主组织移植对于广泛的皮肤缺陷是有限的,因为供体组织的可用性不足.
生物制造的皮肤移植在严重情况下为恢复皮肤完整性和功能提供了潜在的解决方案.

研究的目的:

审查皮肤组织工程中的生物打印现状.
讨论各种生物打印技术,材料,细胞类型和血管化策略.
突出生物打印结构作为大规模伤口修复的潜在皮肤移植替代品.

主要方法:

探索不同的生物打印技术,包括层次聚合,体积,喷墨,激光辅助和基于挤压的方法.
讨论适合的材料和细胞类型,以创建皮肤结构.
对实现移植血管化的策略的审查.

主要成果:

生物打印允许精确地将皮肤细胞沉积到所需的模式中,以创建功能性的皮肤替代品.
这些生物打印结构可以加速伤口愈合并恢复皮肤的生理功能.
各种生物打印技术显示出产生患者特异性皮肤移植的潜力.

结论:

生物打印皮肤结构代表了治疗大规模皮肤缺陷的重大治疗进步.
这项技术解决了重建外科手术中自身组织可用性的局限性.
对材料,细胞来源和血管化的进一步研究对于临床转化至关重要.

关键词:

生物打印是一种生物打印技术.皮肤移植皮肤移植皮肤替代品皮肤替代品

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