急性淋巴细胞白血病中的CAR T细胞:当前状况和未来前景
Abdulrahman H Almaeen1, Mohamed Abouelkheir2,3
1Department of Pathology, Pathology Division, College of Medicine, Jouf University, Sakaka 72388, Saudi Arabia.
Biomedicines
|October 28, 2023
概括
化学抗原受体 (CAR) T细胞疗法为复发性或耐火性急性淋巴细胞白血病 (ALL) 提供了一个有前途的方法. 尽管取得了成功,但正在进行的研究旨在解决限制和不良影响,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 标准的急性淋巴细胞白血病 (ALL) 治疗包括化疗,类固醇和干细胞移植.
- 耐药性或复发性 (R/R) ALL影响到20%的儿科患者和60%的成人患者在初始治疗后.
研究的目的:
- 概述化学抗原受体 (CAR) T细胞疗法在治疗R/R ALL中的应用.
- 总结临床试验结果,并讨论在ALL中使用CAR T细胞治疗的未来方向.
主要方法:
- 对临床试验的审查,调查对ALL的CAR-T细胞疗法.
- 分析CAR-T细胞疗法的疗效,局限性和不良影响.
主要成果:
- 卡尔T细胞疗法在治疗R/RALL方面取得了显著的成功.
- 已批准的CAR T细胞疗法显示出显著的疗效,但仍然存在挑战.
结论:
- 汽车T细胞疗法是R/RALL的宝贵工具,正在进行开发以提高疗效和管理副作用.
- 进一步的研究对于克服成本,不良事件 (细胞因子释放综合征,神经毒性) 和治疗期间复发的可能性等局限性至关重要.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Bone Marrow Sampling and Transplants
341
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
341
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538


