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在台湾人群中使用鼻息肉多原风险评分预测具有或没有鼻息肉的慢性鼻炎的风险预测

Rong-San Jiang^1,2,3,4, I-Chieh Chen¹, Yi-Ming Chen^{1,4,5,6,7,8,9}

¹Departments of Medical Research, Taichung Veterans General Hospital, Taichung 407219, Taiwan.

|October 28, 2023

概括

鼻息肉的多原风险评分 (PRS) 可以预测台湾人的慢性鼻炎 (CRS) 风险. PGS002060 PRS显示出显著的预测价值,特别是对于女性患者的CRS与NP (CRSwNP).

科学领域:

遗传学遗传学是一种遗传学.
耳鼻喉科耳鼻喉科耳鼻喉科
精准医学是一门精准的医学.

背景情况:

单核酸多态 (SNP) 与慢性鼻炎 (CRS) 有关.
对于CRS亚型 (CRSwNP和CRSsNP) 的差异化,多基因风险评分 (PRS) 对鼻息肉 (NP) 的预测能力仍然不清楚.

研究的目的:

调查NP的PRS与NP (CRSwNP) 或没有NP (CRSsNP) 的CRS发展风险之间的关联.
评估在欧洲人群中发展的PRS可转移到台湾人群中,以预测CRS风险.

主要方法:

利用来自台湾精准医学倡议的数据,包括535名CRS患者和5350名对照.
测试了来自英国生物银行的四个NP相关的PRS (PGS000933,PGS000934,PGS001848,PGS002060).
使用后勤回归来评估PRS四分位数中的CRSwNP和CRSsNP风险.

主要成果:

PGS002060显示了最高的预测性能 (CRSsNP的AUC为0.534;CRSwNP的AUC为0.588).
较高的PGS002060水平显著增加了CRSsNP风险的1.48倍和CRSwNP风险的2.32倍.
在最高PRS五分位数中的女性CRSwNP患者与最低五分位数相比,风险增加了3.01倍.

结论:

来自欧洲人群的NP的PRS可以预测台湾人的CRS风险.
PGS002060是一种有前途的PRS,用于识别患有CRSsNP和CRSwNP风险较高的人.
这些发现强调了PRS在个性化CRS风险评估中的潜在实用性,特别是在特定的人口群体中,如女性CRSwNP患者.

关键词:

慢性犀牛鼻炎是一种慢性鼻炎.鼻腔多重体是指鼻腔多重体.多基因风险评分多基因风险评分.

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