通过将固体分散技术与基于黑油的自我纳米乳化药物输送系统相结合,开发一种多功能口服剂型
Abdelrahman Y Sherif1,2, Ahmad Abdul-Wahhab Shahba1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 1145, Saudi Arabia.
Biomedicines
|October 28, 2023
概括
这项研究开发了一个稳定的固体分散 (SD) 系统,使用基于黑油的自我纳米乳化药物递送系统 (SNEDDS) 来改善兰索普拉 (LZP) 的递送. 使用Pluronic F-127的冷化SD显示出增强的LZP溶解和稳定性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 兰索普拉 (LZP) 具有较差的水溶性,阻碍了口服吸收,用于治疗与酸有关的胃肠道疾病.
- 黑油 (BSO) 具有已知的胃保护性,表明其在组合疗法中的潜力.
- 开发先进的药物输送系统对于提高LZP等难溶药物的疗效至关重要.
研究的目的:
- 创建一个稳定的,多功能配方,将固体分散 (SD) 技术与使用BSO的生物活性自纳米乳化药物递送系统 (SNEDDS) 结合起来.
- 为了协同增强兰索普拉 (LZP) 的输送和治疗效果.
- 评估开发的LZP载荷系统的物理化学特性,稳定性和体外溶解.
主要方法:
- 使用BSO,Transcutol P和Kolliphor EL.制备LZP装载的SNEDDS.
- 通过微波辐射和用各种聚合物冷化生产固体分散物 (SDs).
- 使用粒子大小分析,泽塔潜力,SEM,DSC,PXRD和体外溶解试验进行表征.
- 在加速条件下评估化学和物理稳定性.
主要成果:
- 配方实现了纳米尺寸范围 (<500 nm).
- 在破坏LZP结晶性方面,冷化证明比微波加热更有效.
- 使用Pluronic F-127的冷化SDs显示LZP溶解效率增加了3.5倍,并在一个月内保持>97%的化学稳定性.
- 结合的SD和SNEDDS方法表明了配方依赖的协同效应.
结论:
- 与基于BSO的SNEDDS集成的冷化LZP-Pluronic F127 SD提供了一个稳定有效的LZP输送系统.
- 这种多功能系统有望优化LZP和生物活性成分的胃肠道输送.
- 该研究强调了结合SD和SNEDDS的潜力,以提高难以溶解化合物的药物输送.
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