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生物玻璃和维生素D3涂层用于植入物:骨质整合和防腐蚀保护
Irina Negut1, Gratiela Gradisteanu-Pircalabioru2,3,4, Mihaela Dinu5
1National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, P.O. Box MG 36, 077125 Magurele, Romania.
Biomedicines
|October 28, 2023
概括
通过MAPLE合成的新型生物活性玻璃 (BG) 和维生素D3 (VD3) 薄膜改善了植入物的骨质整合和耐腐蚀性. BG+VD3_025膜表现出极好的生物相容性和细胞粘附性,而不会引起炎症.
科学领域:
- 生物材料科学 生物材料科学
- 表面工程是什么?表面工程是什么?
- 生物医学工程 生物医学工程
背景情况:
- 植入物广泛用于骨科和牙科.
- 改善植入物骨质整合和耐腐蚀性对于长期成功至关重要.
- 生物活性玻璃 (BG) 和维生素D3 (VD3) 以其骨质生成和生物相容性特性而闻名.
研究的目的:
- 在Ti型表面上合成和表征MAPLE沉积的BG和VD3薄膜.
- 为了评估这些薄膜的骨融合潜力和防腐蚀保护.
- 评估薄膜的体外生物相容性,细胞毒性和炎症反应.
主要方法:
- 马普尔 (矩阵辅助脉冲激光蒸发) 沉积BG和VD3.
- 用FTIR,SEM和AFM进行化学和形态表征.
- 在体外细胞毒性 (LDH测定) 和生物相容性 (活力测定) 与HDF细胞.
- 光显微镜用于细胞形态评估.
- 用于炎症性细胞因子分析的ELISA (IL-6,IL-10).
- 滴法用于湿度和电化学阻抗光谱用于耐腐蚀性.
主要成果:
- MAPLE沉积保存了BG和VD3膜的化学完整性.
- BG+VD3_025样本表现出最佳的静脉测量和功能组.
- SEM和AFM揭示了促进细胞粘附的不规则表面.
- BG57+VD3_025薄膜显示出优异的生物相容性和细胞活力.
- 没有观察到显著的细胞毒性或主要的细胞变化.
- 薄膜没有改变HDF细胞的亲和抗炎特征.
- BG57+VD3_025涂层表面的接触角为54.65°,表明了改善的湿透性.
结论:
- 用MAPLE合成的BG和VD3薄膜增强了Ti样植入物表面.
- BG+VD3_025配方具有出色的生物相容性和骨质整合潜力.
- 这些电影为改善牙科和骨科植入物提供了一个有希望的策略.
- 开发的涂层提供了增强的生物相互作用和防腐蚀保护.
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