寒冷大气等离子体和氧活性纳米粒子的协同抗菌效应
Artem M Ermakov1,2,3, Vera A Afanasyeva1,2, Alexander V Lazukin4
1Hospital of the Pushchino Scientific Center of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Biomedicines
|October 28, 2023
概括
冷等离子体与CeF3等金属化物纳米颗粒相结合,显示出强大的协同抗菌效应. 这种组合有效地破坏细菌DNA和细胞壁,为治疗细菌疾病提供了一种新的方法.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
背景情况:
- 冷等离子体 (CAP) 和金属氧化物纳米粒子因其抗菌性质而得到认可.
- 研究CAP和纳米颗粒组合的协同抗菌作用对于开发新疗法至关重要.
研究的目的:
- 评估结合冷等离子体与氧化 (CeO2),化 (CeF3) 和氧化 (WO3) 纳米粒子对大肠杆菌的抗菌作用.
- 评估CeF3纳米颗粒在细菌疾病中联合治疗的潜力.
主要方法:
- 研究了CAP和纳米颗粒对甲板上的大肠杆菌殖民地生长的联合作用.
- 通过蓝白殖民地测定和RAPD-PCR对细菌DNA进行评估的突变效应.
- 使用原子力显微镜研究细胞壁损伤.
主要成果:
- CAP和氧化还原活性金属氧化物纳米颗粒 (RAMON) 的组合显示出协同抗微生物效应,超过了单个药物.
- 与CeF3相结合的CAP对等离子体DNA具有最高的变种作用,是最有效的抗微生物剂,导致细胞壁损伤.
- 与WO3结合的CAP对细菌基因组DNA最有效.
结论:
- 将CAP与氧化还原活性金属氧化物或金属化物纳米颗粒相结合,可以产生强大的协同抗菌效应.
- 这种组合导致显著的等离子体和基因组DNA损伤,以及细胞壁损伤.
- CeF3纳米颗粒表现出强大的抗微生物和破坏DNA的作用,标志着一个新的发现.
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