在初级Sjögren综合征中循环的CD8+T细胞子集
Igor Kudryavtsev1, Stanislava Benevolenskaya1, Maria Serebriakova1
1Federal State Budgetary Institution "Almazov National Medical Research Centre" of the Ministry of Health of the Russian Federation, St. Petersburg 197341, Russia.
主要Sjögren综合征 (pSS) 涉及CD8+ T细胞的免疫功能障碍. 研究表明,pSS患者的细胞毒性Tc1细胞减少,调节性Tc2/Tc17细胞增加,影响疾病的发展.
科学领域:
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 主要Sjögren综合征 (pSS) 是一种自身免疫性疾病,其特征是外分泌腺损伤.
- CD8+ T 淋巴细胞参与了pSS的发病过程,特别是通过骨损伤.
研究的目的:
- 为了研究pSS.患者循环CD8+T细胞子集的不平衡.
- 分析pSS中CD8+T细胞子集和临床参数之间的关系.
主要方法:
- 使用流式细胞计量来列出CD8+T细胞成熟阶段和"极化"子集.
- 分析包括34名pSS患者和34名健康对照,使用CD62L,CD28,CD27,CD45RA,CD45,CXCR5,CCR6,CXCR3和CCR4.4等标记.
主要成果:
- 与对照组相比,pSS患者表现出更高数量的天真CD8+ T细胞和更低比例的效能记忆CD8+ T细胞.
- 在pSS患者中观察到细胞毒性Tc1 CD8+ T细胞的减少和调节性Tc2和Tc17 CD8+ T细胞的增加.
- Tc1细胞子集与疾病标志物 (IgG,RF,希尔默测试,唾液流) 有负相关性,而Tc2细胞子集显示出正相关性.
结论:
- CD8+T细胞中的免疫功能障碍,特别是Tc1,Tc2和Tc17子集的改变,对原发性Sjögren综合征的发病有显著的贡献.
- 这些发现凸显了CD8+ T细胞子集在pSS发育和进展中的潜在作用.
更多相关视频
07:25Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
07:39Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
相关概念视频
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cell-mediated Immune Responses
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
