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系统性红斑狼患者的血液复合分数

Júlia Mercader-Salvans¹, María García-González², Juan C Quevedo-Abeledo³

¹Division of Dermatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain.

|October 28, 2023

概括

尽管细胞数量较低,但系统性红斑狼 (SLE) 患者的血液学评分,如中性粒细胞与淋巴细胞的比率 (NLR) 较高. 这些标记物与疾病特征的相关性有限,但与补充系统激活有关.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

全血细胞计衍生的比率在各种疾病中作为炎症生物标志物.
血液学得分,包括中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SIRI) 是已确立的炎症标志物.
系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,具有多样化的临床表现.

研究的目的:

为了研究血液学分数 (NLR,MLR,PLR,SIRI) 和疾病表现在SLE患者的大队伍之间的关系.
为了比较这些SLE患者和健康对照之间的血液学分数.
确定这些分数与SLE的临床和实验室特征的关联,包括疾病活动,严重程度,损伤和补体激活.

主要方法:

招募了284名SLE患者和181名年龄和性别匹配的健康对照.
为所有参与者计算NLR,MLR,PLR和SIRI.
在患者中评估SLE疾病活性 (SLEDAI-2K),严重程度 (Katz指数) 和损伤 (SLICC-DI).
使用多变量线性回归来分析差异和关联,并对共变量进行调整.

主要成果:

与对照组相比,SLE患者的中性粒细胞,单细胞,淋巴细胞和血小板的原始计数较低.
尽管细胞数量较低,但NLR,MLR和PLR在SLE患者中明显高于多变量调整后对照组;SIRI没有.
血液学分数与大多数疾病特征之间观察到有限的关系. 然而,卡茨严重性指数显示出与SIRI,NLR和MLR的积极关联.
替代补充级联激活和较低的C3水平与较高的NLR,MLR和PLR显著相关.

结论:

血液综合得分,包括NLR,MLR和PLR,在SLE患者中与对照人群相比独立地升高,即使存在细胞衰竭.
这些血液学分数与特定的SLE疾病特征的关联通常是有限的.
在SLE患者中,发现的最一致的关联是血液学得分升高与补体系统激活标记之间的关联.

关键词:

血液学综合评分血液学综合评分系统性炎症反应指数系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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