新型冠状病毒疾病在患有全身性氨基粉症的患者中的病态形态特征
Liudmila Mikhaleva1, Zarina Gioeva1, Valery Varyasin2
1Avtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Biomedicines
|October 28, 2023
概括
患有全身性氨基粉症的患者面临严重的COVID-19结果. 这项研究分析了尸检结果,揭示了这些患者的多器官参与和死亡风险增加.
科学领域:
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- 系统性粉症涉及粉样纤维在器官中的沉积.
- COVID-19和粉样粉症共享多器官参与,增加严重的发病和死亡风险.
- 同时感染对粉样化症患者构成重大威胁.
研究的目的:
- 为了调查COVID-19和全身性氨基粉症患者的病态学发现.
- 为了确定COVID-19对系统性粉样症进展的影响.
- 分析COVID-19的临床过程和结果在患有先前存在的amyloidosis的患者.
主要方法:
- 对22名患者的尸检记录进行了病态形态分析.
- 免疫组织化学粉样蛋白类型 (AA,AL 兰巴,AL 卡帕,ATTR).
- 针对SARS-CoV-2肺组织中的Spike (S) 蛋白的免疫组织化学染色.
主要成果:
- 系统性氨基粉症在55%的病例中被诊断为死前,在45%的病例中被诊断为尸检时.
- 鉴定出了A (AA) 类粉样性粉样性粉症 (23%),AL 兰巴 (32%),AL 卡帕 (9%) 和ATTR 类粉样性粉症 (36%).
- 在59%的病例中,在II型肺细胞中检测到SARS-CoV-2尖端蛋白.
- 患者表现出积极的COVID-19,多器官衰竭,死亡率增加.
结论:
- 系统性amyloidosis患者容易发生COVID-19的严重临床过程.
- 多器官衰竭和高死亡率是COVID-19的amyloidosis患者的重大风险.
- 尸体解剖分析提供了对这两个条件之间的相互作用的关键见解.
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