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在没有并发症的1型糖尿病的年轻患者中,TNF-a,IL-35,VEGF和皮肤微血管功能障碍之间的关系

Jolanta Neubauer-Geryk¹, Melanie Wielicka^1,2, Małgorzata Myśliwiec³

¹Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gdańsk, 80-210 Gdansk, Poland.

|October 28, 2023

概括

在年轻的1型糖尿病患者中,较低的微血管功能与较高的VEGF,TNF-α和HbA1c水平有关,这表明代谢记忆和细胞因子失衡影响并发症.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
微循环研究微循环研究

背景情况:

1型糖尿病 (T1D) 涉及微血管并发症.
了解功能障碍的早期标志物对于T1D管理至关重要.
皮肤微循环反映了系统性血管健康.

研究的目的:

研究年轻T1D患者免疫标记和皮肤微循环功能障碍之间的关系.
为了确定早期T1D中微血管功能障碍的预测因素.
探索血清生物标志物和血糖控制在微血管健康中的作用.

主要方法:

爪毛细镜评估了反应性高血压前后的微血管功能,在12个月后重复.
患者根据基线毛细血管覆盖率 (coverageBASE) 分层.
测量了VEGF,TNF-α和IL-35的血清水平; HbA1c被追踪了12个月,并分析了前两年.

主要成果:

患有较低基线毛细血管覆盖率 (<16.85%) 的患者表现出较高的VEGF和TNF-α水平.
这些患者在诊断后的头两年内也显示出较高的HbA1c水平.
这些发现表明,炎症,血管标志物和血糖史之间存在联系.

结论:

糖尿病并发症的发展受到代谢记忆的影响.
益和抗炎细胞因子的不平衡起着重要作用,无论血糖控制如何.
早期的微血管评估和免疫标记的监测可以帮助预测T1D并发症.

关键词:

它们的IL-35是IL-35.这就是TNF-α.在VEGF中,VEGF是VEGF.抗炎性细胞因子是一种抗炎性细胞因子.孩子们的孩子们的孩子们的孩子们微血管病变是一种微血管病变.有助于炎症的细胞因子.益血管性细胞因子皮肤的微循环.第1类糖尿病糖类糖尿病

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