关于冠状动脉疾病的表观遗传学和个性化医学的方法的全景
Marcello Bergonzini1, Francesco Loreni2, Antonio Lio1
1Department of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Biomedicines
|October 28, 2023
概括
表观遗传修饰,如DNA甲基化和非编码RNA,驱动冠状动脉疾病 (CAD) 的进展. 了解这些表观遗传变化是开发个人化CAD医学方法的关键.
科学领域:
- 心血管研究研究心血管研究
- 表观遗传学和基因组学
- 个性化医疗是个性化的医疗.
背景情况:
- 冠状动脉疾病 (CAD) 的发病因子受到表观遗传修饰的显著影响.
- 表观遗传过程包括DNA / 基因组甲基化,乙化,酸化和调节性RNA (miRNA, lncRNA, circRNA).
- 这些修改改变基因表达以应对环境和生活方式因素,影响CAD风险.
研究的目的:
- 为CAD中的表观遗传机制提供全面的概述.
- 探索表观遗传学在CAD病变发生中的作用.
- 突出表观遗传学对个人化医学在CAD中的影响.
主要方法:
- 这是一篇综述性文章,综合了目前关于表观遗传学和CAD的知识.
- 它检查了已建立的表观遗传机制和新兴的调节性RNA.
- 该评论讨论了表观遗传数据与遗传和生活方式因素的整合.
主要成果:
- 表观遗传变化对在CAD中参与炎症,氧化应激,脂质代谢和血管功能的基因进行调节.
- 这些变化可能起源于生命的早期,增加长期的CAD易感性.
- 遗传和表观遗传因素之间的相互作用为改善诊断和治疗提供了潜力.
结论:
- 表观遗传修饰对于CAD的发展和进展至关重要.
- 个性化医疗策略可以利用表观遗传的见解来定制CAD干预措施.
- 对表观遗传机制的进一步研究有望实现更精确的CAD风险分层和治疗.
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