基于临床和神经心理症状的等级集群分析揭示了纤维肌痛的不同亚组:基于人口的队列研究
Sara Maurel1, Lydia Giménez-Llort2,3, Jose Alegre-Martin4,5
1Department of Medicine, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Biomedicines
|October 28, 2023
概括
这项研究根据临床症状和心理因素确定了四个不同的纤维肌痛 (FM) 患者群. 这些发现有助于开发纤维肌痛个性化治疗方法.
科学领域:
- 类风湿病学 类风湿病学
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 纤维肌痛 (FM) 呈现出广泛的肌肉骨疼痛和众多的并发症.
- 了解患者的异质性对于有效的管理至关重要.
- 目前的治疗目标需要根据不同患者的个人资料进行细化.
研究的目的:
- 为了确定纤维肌痛患者的不同集群.
- 分析核心临床症状和神经心理相关疾病.
- 发现个性化FM干预的潜在治疗点.
主要方法:
- 一项基于人口的队列研究,涉及251名成年纤维肌痛患者.
- 使用K-中位数的层次集群分析.
- 数据包括身体症状,情绪状态和神经心理变量.
主要成果:
- 从全球分析中,出现了四个不同的患者群.
- 临床症状分为疲劳/工作困难,疼痛和焦虑/抑郁子组.
- 神经心理变量形成了两个相反的群体:高负面影响/投降与高接受/正念.
结论:
- 纤维肌痛患者的个人资料是多样化的,超越纯粹的生物医学模型.
- 结果支持综合的神经生物学,心理和社会因素相互作用.
- 区分FM亚型是个性化治疗策略的关键.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
50
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
50
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K


