双相情绪障碍患者的炎症标志物,他们犯了罪行,以及与犯罪行为的关系
Burcu Sırlıer Emir1, Sevler Yıldız1, Aslı Kazğan Kılıçaslan2
1Department of Psychiatry, Elazığ Fethi Sekin City Hospital, 23100 Elazığ, Turkey.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
系统性炎症标志物,包括低血小板和HDL-c水平,与双相情感障碍 (BD) 患者的犯罪行为有关. 这些炎症参数可以作为BD的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 双极性障碍 (BD) 与复杂的病理生理学有关.
- 系统性炎症在各种心理健康状况中起作用.
- 犯罪行为和BD之间的联系需要进一步调查潜在的生物机制.
研究的目的:
- 研究炎症参数在双极性障碍 (BD) 病理学中的作用.
- 识别潜在的生物标志物,将犯罪行为与BD联系起来.
- 探索BD患者的炎症标志物的相互作用,包括有或没有犯罪行为.
主要方法:
- 追溯研究包括1029名参与者:343名违规BD患者,343名非违规BD患者和343名健康对照.
- 测量中性粒细胞,淋巴细胞,单细胞和血小板数量.
- 高密度脂蛋白胆固醇 (HDL-c) 水平和各种炎症指数 (SII,SIRI,NHR,LHR,MHR,PHR) 的评估.
主要成果:
- 在SII,SIRI,NHR,LHR,MHR,PHR,中性粒细胞和单细胞值中,在不同组中观察到显著的差异 (p < 0.001).
- 与非侵权性BD患者相比,侵权性BD患者的淋巴细胞数量较高 (p = 0.04),血小板数量显著降低 (p = 0.015) 和HDL-c水平 (p < 0.001).
- 双极性障碍,缺乏积极的精神治疗,躁狂发作和低血小板/HDL值是犯罪参与的危险因素.
结论:
- 系统性炎症与BD的病理生理学有关,无论犯罪行为如何.
- 特定的炎症标志物,特别是低血小板和HDL-c水平,与BD患者的犯罪行为有关.
- 这些发现突出了炎症参数作为生物标志物的潜力,以了解BD与犯罪行为之间的关系.
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