通过益生菌细菌Lactococcus Sp. Sp. 减弱MOG诱导的寡类细胞中的免疫性. 这是PO3PO3PO3PO3PO3
Ashraf Khalifa1,2, Hairul-Islam Mohamed Ibrahim1,3, Abdullah Sheikh4
1Biological Science Department, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
研究人员从牛奶中分离出Lactococcus raffinolactis PO3,证明了它对神经炎症的益生菌潜力. 这种新型益生菌在细胞模型中减弱了关键的炎症标志物,这表明未来对多发性硬化症等疾病的治疗应用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 牛奶含有重要的营养素和微生物组,其中益生菌可调节免疫力并对抗炎症.
- 益生菌提供了对各种疾病的潜在保护,包括神经炎症疾病.
研究的目的:
- 从牛奶中分离出具有神经炎症益生菌潜力的新型细菌物种.
- 为了在体外评估一个有前途的分离物的神经抗炎活性.
主要方法:
- 六个牛奶样本被选为具有益生菌特征的细菌分离物 (catalase测试,血液溶解,酸/胆耐受性,粘附性,水性).
- 在16S rRNA基因测序中,分离PO3被确定为Lactococcus raffinolactis.
- 评估了人类寡类细胞 (HOG) 细胞系的神经抗炎活性,使用STAT-3,MBP,GFAP和GLAC等标记物.
主要成果:
- 获得了9种细菌分离物;PO3表现出显著的益生菌特性,包括对酸性,胆汁和高盐条件的耐受性.
- 乳球球菌拉菲诺拉克蒂斯PO3通过减弱信号转换器和转录激活剂 (STAT-3) 水平,显示出神经保护作用.
- 在细胞模型中,PO3治疗增加了髓基本蛋白 (MBP),质纤维酸蛋白 (GFAP) 和GLAC的表达.
结论:
- 乳球球菌 (Lactococcus raffinolactis PO3) 是对抗神经炎症疾病的益生菌开发的一个有希望的候选者.
- 进一步的体内研究是有必要的,以探索其治疗潜力,如多发性硬化症等疾病.
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