在急诊室内鼻腔止痛疗法的有效性
Christian Zanza1,2, Francesco Saglietti3, Jacopo Davide Giamello4
1Italian Society of Prehospital Emergency Medicine-SIS 118-Taranto, 74121 Taranto, Italy.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
鼻内止痛提供了一个安全有效的替代方案,用于急诊部 (ED) 的急性疼痛管理,与静脉注射方法相似. 这种方法提供了快速吸收和缓解疼痛,利用药物,如芬太尼和胺.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 疼痛是急诊室 (ED) 中普遍存在且经常未得到充分治疗的症状.
- 标准的急性疼痛缓解方法包括静脉注射 (IV),口服 (PO) 和肌内注射 (IM).
- 鼻内 (IN) 止痛正在被探索作为一种潜在的急性疼痛管理替代方案.
研究的目的:
- 将鼻内 (IN) 止痛疗法的安全性和有效性与ED中急性疼痛管理的常规途径进行比较.
- 分析不良事件 (AEs) 的发生率和严重程度,以及需要通过IN给药进行救援止痛.
- 评估IN镇痛作为一种可行的替代方案,以减少患者的痛苦和延迟疼痛管理.
主要方法:
- 1992年至2022年间发表的随机临床试验 (RCT) 的叙述性综述.
- 在主要的数据库中进行了搜索:Pubmed/Medline,Scopus,EMBASE,Cochrane图书馆和受控试验注册.
- 分析包括来自20个涉及2098名患者的RCT的数据,将IN止痛与静脉 (IV) 止痛进行比较.
主要成果:
- 与静脉注射止痛药相比,鼻内止痛药在不良影响方面没有统计上的差异.
- 鼻内注射显示出迅速发作和快速吸收,促进有效的疼痛缓解.
- 有前途的鼻入药物包括芬太尼和胺,可以简单安全地使用.
结论:
- 鼻内止痛是一种安全有效的替代方案,用于管理急性疼痛在急诊室.
- 它的快速吸收和有效性,与IV途径相比,使其成为一个有价值的选择.
- 鼻腔内注射,特别是芬太尼和胺,提供了一种实用的方法,可以及时缓解疼痛.
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