在OSA患者中,COPD是否是肌肉心脏损伤和心脏壁压力的决定因素?
Athanasios Voulgaris1,2, Kostas Archontogeorgis1,2, Ioulianos Apessos2,3
1Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
与阻塞性睡眠呼吸暂停 (OSA) 患者相比,COPD-OSA重叠综合征 (OS) 患者表现出亚临床心肌损伤和壁压力的标志物增加. 这表明OS患者的心血管风险较高,强调需要有针对性的监测.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 慢性肺炎-OSA重叠综合征 (OS) 与心血管疾病 (CVD) 的患病率高于单独的任何一种情况.
- 亚临床心肌损伤和心脏壁压力是OS中心血管疾病风险增加的潜在因素.
研究的目的:
- 调查与阻塞性睡眠呼吸暂停 (OSA) 患者相比,OS患者是否表现出更大的亚临床心肌损伤和壁面压力的负担.
主要方法:
- 该研究包括53名OS患者和53名OSA患者,所有这些患者都没有确定的心血管疾病.
- 透视视镜,肺功能测试,血清高灵敏性心脏素T (hs-cTnT) 和N-终端亲B型尿素 (NT-proBNP) 用于评估心肌损伤和壁压力.
主要成果:
- 与OSA患者相比,OS患者年龄较大,在睡眠和清醒期间的低血压参数明显较差.
- 与OSA患者相比,OS患者的hs-cTnT和NT-proBNP水平显著升高.
- 多变量分析表明,NT-proBNP和hs-cTnT水平与年龄和睡眠期间的平均SpO2相关.
结论:
- 患有COPD-OSA重叠综合征的患者表现出较高水平的hs-cTnT和NT-proBNP.
- 这些发现表明,与OSA患者相比,OS患者的亚临床心肌损伤和心脏壁压力的可能性增加.
- 这表明与OS相关的心血管风险概况较高.
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