喘息患者的呼出氧化和嗅觉功能障碍:与慢性鼻炎的关联
Takashi Oda1, Hiroshi Iwamoto2, Sachio Takeno1
1Department of Otorhinolaryngology, Head & Neck Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
喘患者的嗅觉功能障碍通常与慢性鼻炎有关. 异性慢性鼻炎 (ECRS) 常见于高分量呼出的氧化 (FeNO),而非异性慢性鼻炎 (NCRS) 与较低的FeNO水平有关.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏 免疫学 免疫学
背景情况:
- 嗅觉功能障碍是喘患者的一个关键标志,经常与上呼吸道疾病并存.
- 了解喘嗅觉功能障碍的原因对于有效管理至关重要.
研究的目的:
- 研究喘患者嗅觉功能障碍的原因.
- 探索嗅觉功能障碍与喘中部分排气的氧化 (FeNO) 水平之间的关系.
主要方法:
- 一项涉及47名喘患者的研究,在广岛大学医院 (2012-2020年) 评估嗅觉功能障碍.
- 嗅觉功能障碍的病因被评估并根据患者的FeNO水平进行分类.
主要成果:
- 在47名喘患者中,有30人表现出嗅觉功能障碍,慢性鼻炎是最常见的原因 (77%).
- 乙性慢性鼻炎 (ECRS) 是高FeNO (≥25ppb) 的喘患者的主要原因,而非乙性慢性鼻炎 (NCRS) 在低FeNO (<25ppb) 的患者中占主导地位.
- 与其他组相比,患有嗅觉功能障碍和高FeNO (74%) 的喘患者的ECRS患病率显著更高.
结论:
- 在高FeNO的喘患者中,ECRS是嗅觉功能障碍的主要原因,而NCRS在低FeNO患者中更为普遍.
- 无论是ECRS还是NCRS都是导致喘中的嗅觉功能障碍的重要因素.
- 这项研究加强了喘患者经历嗅觉功能障碍的上呼吸道和下呼吸道炎症之间的联系.
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