人类免疫缺陷病毒患者凝血参数趋势
Bashir Abdrhman Bashir1, Mohamed Hassan Mohamed2, Mohamed A Hussain3
1Department of Hematology, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan 33312, Sudan.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
艾滋病毒感染对凝血产生影响,导致苏丹患者的血栓性血栓性细胞缺陷性紫外线类事件和抗脂抗体增加. 需要进一步的研究来证实这些发现.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染已知会破坏凝血通路.
- 艾滋病毒患者可能会表现出更高的血栓细胞减小,血栓形成和自身抗体的倾向,使诊断复杂化.
- 了解艾滋病毒患者的凝血参数趋势对于有效管理至关重要.
研究的目的:
- 在被诊断为艾滋病毒的苏丹患者中调查凝血参数趋势.
- 在这个队列中评估血栓性血栓性细胞缺陷性紫外线类事件和抗脂抗体的流行率.
主要方法:
- 在2018年1月至2019年12月期间,苏丹国家艾滋病计划 (SNAP) 进行了一项涉及44名艾滋病毒患者的横截面研究.
- 评估的凝血参数包括前热血素时间 (PT),部分血栓形成时间 (PTT),血栓时间 (TT),D-二次体 (DD),血红蛋白 (HB),总淋巴细胞计数 (TLC),血小板计数 (PLT) 和ADAMTS13.
- 在HIV患者和对照组之间进行了比较.
主要成果:
- 在13.6%的艾滋病毒患者中观察到类似于血栓性血栓塞性紫外线的事件,而27.2%的抗脂抗体检测呈阳性.
- 与对照组相比,艾滋病毒患者的HB,TLC和PLT水平显著降低 (p=0.000,p=0.000,p=0.050).
- 在艾滋病毒患者中发现PTT,TT和DD值升高 (p=0.000),而PT和ADAMTS13没有显著差异 (p=0.613,p=0.266).
结论:
- 这项研究强调了血栓性血栓细胞性紫外线类事件的发生以及苏丹艾滋病毒患者中抗脂抗体的显著流行.
- 凝血异常,包括延长的PTT,TT和升高的DD,在这个人群中很普遍.
- 建议进行进一步的研究以验证这些发现,并探索诊断和治疗方面的影响.
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